Ace Infectious also provides research services for membrane proteins (MPs) other than H. pylori adhesins to help in the overall understanding of H. pylori MPs.
H. pylori belong to the group of Gram-negative bacteria with outer and inner membranes. H. pylori contains more than 60 outer membrane genes. The most studied adhesins belong to the outer MPs. In addition to adhesins, there are also efflux pump proteins and iron-regulated proteins. The inner MPs of H. pylori include Urel, an important protein for H. pylori survival, and some efflux pump proteins. These outer and inner MPs play important roles in the survival, pathogenesis, and drug resistance of H. pylori. For example, nickel import and export MPs are essential for the survival and pathogenesis of H. pylori as they affect the activity of hydrogenase and urease of H. pylori.
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